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Spermidine Trihydrochloride Definition, Benefits, Toxicity, and Where to Buy

Spermidine trihydrochloride is a widely used chemical with applications in reagents, fertilizers, cosmetics, dietary supplements, etc. So do you know about spermidine trihydrochloride? Such as definition, toxicity, safety, benefits, etc.

In this article, Natural Micron will introduce spermidine trihydrochloride in detail.

Then you will learn the following:

What is spermidine trihydrochloride?

Spermidine trihydrochloride is a compound derived from spermidine. Spermidine trihydrochloride specifically refers to spermidine that is chemically combined with three molecules of hydrochloric acid (HCl) to form a salt. It is usually a white or off-white crystalline powder that is soluble in water.

Spermidine is a naturally occurring polyamine that exists in ribosomes and living tissues (such as microorganisms, plants, and animals) and has various metabolic functions in organisms. For example, inhibiting neuronal synthetase, binding and precipitating DNA, triggering autophagy, and preventing Alzheimer’s disease. Spermidine was originally isolated from semen.

Spermidine Trihydrochloride VS Spermidine

Spermidine trihydrochloride is a compound derived from spermidine, the main difference between them lies in the two aspects of chemical form and use, the details are as follows:

Chemical form:

Spermidine is a naturally occurring polyamine, which means that it exists in its base form as a free, unbound molecule.

Spermidine trihydrochloride is the salt form of spermidine. It is produced by chemically combining spermidine with three hydrochloric acid (HCl) molecules.


Spermidine is found in a variety of organisms, including plants, animals, and bacteria.

Spermidine trihydrochloride is usually synthesized in a laboratory setting.

Main uses:

Spermidine triggers autophagy, removing damaged components and supporting cell regeneration. Supplementing spermidine can resist aging and protect nerves.

Spermidine trihydrochloride is commonly used in scientific research and laboratory experiments that require precise dosage and controlled conditions. Researchers use it as a source of spermidine to study its effects on cells and biological processes.

What are the benefits of spermidine trihydrochloride?

Supplementing or consuming enough spermidine in your diet has many health benefits. Such as anti-aging, reducing cognitive decline, etc.

Spermidine trihydrochloride and cellular autophagy

Spermidine’s ability to trigger autophagy is thought to be its primary mechanism for slowing aging and extending lifespan, and it has been shown to induce autophagy in mouse hepatocytes, worms, yeast, and fruit flies.

Anti-inflammatory properties

Chronic inflammation prevents healthy tissue from regenerating, causes immune cell dysfunction, and can even accelerate the aging of healthy cells. Spermidine trihydrochloride can reduce this chronic inflammation and may slow cell and tissue aging.


Taking spermidine trihydrochloride increases lifespan and prevents liver fibrosis and hepatocellular carcinoma. The same goes for a polyamine-rich diet. There’s also some evidence that it can improve resistance to stress.

Reduce cognitive decline

Research published in 2021 in the journal Cell Reports details dietary spermidine improving cognition and mitochondrial function in flies and mice.

Cardiovascular health

In a 2016 study, spermidine was found to reverse the aging clock and improve cardiovascular function in older mice. At the organ level, aged mice given spermidine showed improvements in heart structure and function. Metabolism in these mice also improved due to the restoration of mitochondrial structure and function following spermidine supplementation.

Toxicity and safety of spermidine trihydrochloride

Spermidine trihydrochloride seems to be a safe compound, but it can also show certain toxicity under certain conditions and affect people’s health.

Irritation: Spermidine trihydrochloride is irritating to the eyes and skin. When working with this chemical, appropriate personal protective equipment, including gloves and goggles, must be worn to minimize the risk of contact with skin or eyes.

Inhalation: Avoid breathing the dust or vapor of spermidine trihydrochloride. If accidentally inhaled, seek medical attention immediately.

Allergic reactions: In some individuals, skin contact with spermidine trihydrochloride may trigger an allergic reaction. Get medical help if you notice any signs of an allergic reaction, such as itching, redness, or rash.

Safety: Spermidine trihydrochloride is the hydrochloric acid form of spermidine. Since spermidine is a naturally occurring compound, spermidine trihydrochloride is generally considered safe.

Where to buy 98% concentration spermidine trihydrochloride?

The synthesis of high-concentration spermidine trihydrochloride usually requires certain technical means, and small doses of 98% spermidine trihydrochloride can be purchased in some laboratories. If you need a large quantity of 98% spermidine trihydrochloride, you can contact us (Natural Micron), we will provide you free samples for your testing. Moreover, we provide customized synthesis services to help you optimize your synthesis paths and methods.

You can view this page to learn more about our products.

Spermidine Trihydrochloride (CAS: 334-50-9)

In the end

Spermidine trihydrochloride is widely used and has many benefits. Through this article, I hope you have a certain understanding of the definition, differences, benefits, toxicity, and safety of spermidine trihydrochloride. If you need to buy high-concentration spermidine trihydrochloride, contacting us is a good choice.

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