Natural Micron Pharm Tech


Trimesic acid (CAS: 554-95-0)

Trimesic acid is an organic compound. White to light yellow crystalline powder. It is an important chemical raw material, used as a pharmaceutical intermediate. 1,3,5-Benzenetricarboxylic acid is also widely used in plastics, artificial fibers, water-soluble alkyl resins, plasticizers, fungicides, antifungal agents, and crosslinking agents, etc., and is also an intermediate for special polymers and resins.

Cas Number: 554-95-0

EINECS Number: 209-077-7

Molecular Formula: C9H6O6

Structure Formula: 

Appearance:  White crystalline powder

Other Name: 1,3,5-Benzenetricarboxylic Acid; Benzene-1,3,5-tricarboxylic acid; BTC, H3BTC, TMA

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Application of Trimesic acid

Trimesic acid is mainly used as an adhesive and in coating materials. It is also used as pharmaceutical intermediates, such as drugs and gene carriers.

It is also widely used in plastics, artificial fibers, water-soluble alkyl resins, plasticizers, fungicides, antifungal agents and crosslinking agents, etc., and is also an intermediate for special polymers and resins.

Parameters of 1,3,5-Benzenetricarboxylic acid

Items Specification
Name Trimesic acid
Other Name 1,3,5-Benzenetricarboxylic Acid; Benzene-1,3,5-tricarboxylic acid; BTC, H3BTC, TMA
Brand Natural Micron Pharm Tech
Cas Number 554-95-0
EINECS Number 209-077-7
Appearance White crystalline powder
Molecular Formula C9H6O6
Structure Formula
Molecular Weight 210.14
Melting Point >300°C(lit.)
Boiling Point 309.65°C (rough estimate)
Solubility 26.3g/l
Purity ≥98%
Place of Origin China
Shelf Life 2 Years
Package 25kg/drum, 675KG/Pallet, small sample available
Storage Store in Dry and Ventilated place with the Room Temperature, Preserved in Original Tight-Closed containers, Keep Away from Light and Heating.

What is trimesic acid?

TMA, H3BTC, and BTC are all called Trimesic acid, 1,3,5-benzonetricarboxylic acid (CAS 554-95-0). It is an organic compound belonging to tricarboxylic acid compounds.

The structure of trimesic acid consists of a benzene ring and three carboxyl groups, and its chemical formula is C6H3(COOH)3. Each carboxyl group (COOH) can react with other compounds to form esters of trimesic acid.

The appearance of trimesic acid is a white crystalline solid with a slightly acidic taste. It is sparingly soluble in water but more soluble in organic solvents like ethanol and acetone.

Trimesic acid is mainly used in the chemical industry as a structural unit for synthesizing various organic compounds. It participates in the esterification reaction to form three polyesters, which are used in polymer chemistry and coatings. In addition, trimesic acid can coordinate with metal ions so that it can be used in metal-organic frameworks (MOFs) and other coordination complexes.

Trimesic acid biological/chemical reaction

  • Esterification reaction: The carboxyl (-COOH) functional group of trimesic acid can react with alcohols to form esterification products.
  • Coordination reaction: The carboxyl functional group of trimesic acid can form a coordination compound with metal ions.
  • Hydrogenation reaction: Under appropriate reaction conditions, some functional groups in trimesic acid may be reduced to hydroxyl or methyl groups.
  • Acid-base neutralization reaction: The carboxyl group in trimesic acid is weakly acidic and can react with the base to form salts.

Trimesic acid uses

Trimesic acid has a wide range of uses and is very important in industrial production. The following are some main uses of trimesic acid.

  • Polymers and Coatings: Trimesic acid is used in the production of polyester resins and coatings to improve the heat and chemical resistance of the polyester material.
  • Metal-organic framework (MOF): Trimesic acid has multiple carboxyl functional groups and can be used as a ligand for metal-organic framework (MOF).
  • Pigments and dyes: Derivatives of trimesic acid are used to prepare certain pigments and dyes. These pigments and dyes are helpful in the paint, ink, and dye industries.
  • Analytical chemistry: Trimesic acid can be used as an analytical chemical reagent for the detection and determination of metal ions and other substances.

Trimesic acid preparation method

Trimesic acid can be synthesized by various methods. One of the common synthetic methods is the oxidation reaction on the benzene ring, which oxidizes the methyl position on the benzene ring to a carboxyl group. In addition, trimesic acid can also be obtained by halogenating the methyl position on the benzene ring, and then reacting with an oxidizing agent.

Here are the specific steps of the benzene epoxidation method:

Preparation of raw materials: Benzene (C6H6) is used as raw material to ensure the purity and quality of raw materials.

Oxidation reaction: Dissolve benzene in an appropriate solvent, usually nitric acid (HNO3) or hydrogen peroxide (H2O2) can be selected as the oxidizing agent. Under appropriate temperature and reaction conditions, the oxidation reaction is carried out.

Preparation of trimesic acid: The oxidation reaction will oxidize the methyl position on the benzene ring to a carboxyl group to obtain trimesic acid. The reaction product can be obtained by crystallization or other purification methods to obtain trimesic acid products with higher purity.

It is worth noting that benzene epoxidation is a common and relatively simple method for the preparation of trimesic acid. However, the actual operation will be different due to factors such as laboratory scale, equipment conditions, and purity requirements. Therefore, it is very difficult to ensure the quality and yield of the product, Natural Micron Pharm Tech provides high-quality, pure, and low-price trimesic acid, contact us now to get a free sample of Trimesic Acid.

Trimesic acid safety and risk


INHALATION: Trimesic acid powder or gas may cause respiratory irritation. Therefore, when handling or handling trimesic acid, ensure good ventilation and avoid inhaling dust or gas.

Contact: Trimesic acid may be irritating to the skin and eyes. When handling, protective gloves and goggles should be worn to avoid direct contact with trimesic acid.

Ingestion: Trimesic acid may be somewhat irritating to the digestive system. Trimesic acid should not be ingested or exposed to the mouth.

Combustion: Trimesic acid is an organic compound that can burn to produce toxic gases and fumes. When using and storing trimesic acid, keep away from fire and high-temperature conditions.


Corrosiveness: Trimesic acid, while not classified as a strong acid, is an organic acid that can be corrosive to some materials and surfaces. When handling, avoid direct contact with metals and other sensitive materials.

Instability: Trimesic acid may be unstable under high temperatures, ultraviolet radiation, and other conditions, which may cause decomposition or produce degradation products. Therefore, exposure to adverse environmental conditions should be avoided when storing and using trimesic acid.

Transportation: Trimesic acid needs to comply with relevant dangerous goods transportation regulations and standards during transportation to ensure safe transportation.

Trimesic acid research and development

Improvement of synthesis method: constantly explore and improve the synthesis method of trimesic acid to increase yield and purity and reduce cost.

Functional application: Trimesic acid, as a compound with a special structure, has a variety of functional groups, so it has potential applications in the preparation of functional materials.

Biomedical application: Studies have shown that trimesic acid and its derivatives may have certain effects on human health. For example, as drug carriers, antioxidants, or bioactive compounds.

Environmental friendliness: Use trimesic acid and its derivatives to synthesize environmentally friendly polymers or adsorbents for wastewater treatment and pollutant removal.

Trimesic Acid CNMN.pdf

Trimesic Acid HNMR.pdf

Trimesic Acid HPLC.pdf

Trimesic Acid TDS.pdf

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