Natural Micron Pharm Tech


Palmitoylethanolamide (PEA CAS: 544-31-0)

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that belongs to the class of nuclear factor agonists. It has been shown to bind to nuclear receptors (NRs) in cells and exert a large variety of biological functions related to chronic pain and inflammation. Cetamide ethanol can be used as organic synthesis intermediates and pharmaceutical intermediates.

Cas Number: 544-31-0

EINECS Number: 208-867-9

Molecular Formula: C18H37NO2

Structure Formula: 

Appearance: White crystal powder

Other Name: N-(2-hydroxyethyl)hexadecanamide; Palmidrol; PEA; N-Palmitoylethanolamine

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Application of Palmitoylethanolamide

In some primary research studies, PEA has been shown to have anti-inflammatory,anti-nociceptive, neuroprotective, and anticonvulsant properties.

N-(2-hydroxyethyl)hexadecanamide is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in the laboratory research and development process and in the chemical and pharmaceutical research and development process.

Parameters of Palmidrol

Items Specification
Name Palmitoylethanolamide
Other Name N-(2-hydroxyethyl)hexadecanamide; Palmidrol; PEA; N-Palmitoylethanolamine
Brand Natural Micron Pharm Tech
Cas Number 544-31-0
EINECS Number 208-867-9
Appearance White crystal powder
Molecular Formula C18H37NO2
Structure Formula
Molecular Weight 299.49
Melting Point 97-98℃
Solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Purity 99% min
Density 0.910±0.06 g/cm3
Place of Origin China
Shelf Life 2 Years
Package 1 kg per Aluminum foil bag /25kg per Drum
Storage Store in Dry and Ventilated place with Room Temperature, Preserved in Original Tight-Closed containers, Keep Away from Light and Heating

What is Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that belongs to the class of nuclear factor agonists. and a member of the N-acylethanolamine family. Therefore, it can also be called N-Palmitoylethanolamine or N-(2-hydroxyethyl)hexadecanamide. The prominent appearance is powder. CAS number is 544-31-0.

Its main functions include anti-inflammatory, antinociceptive, neuroprotective, and anticonvulsant properties.

Uses of Palmitoylethanolamide (PEA):

Palmitoylethanolamide (PEA) is primarily used to regulate inflammation, pain perception and immune response. The following is the main application content.

1. Relief the Pain:

Interaction of PEA with cannabinoid receptors and other receptors involved in pain regulation can be used to relieve chronic pain, including neuropathic pain, inflammatory pain, and chronic pelvic pain.

2. Anti-Inflammatory Agent:

PEA can be used to reduce inflammation in conditions such as arthritis, inflammatory bowel diseases, and neuroinflammatory disorders.

3. Neuroprotection:

The interaction of PEA with the transient receptor potential vanilloid 1 (TRPV1) channel and other receptors can be used for neuroprotection.

4. Immune Modulation:

PEA can help regulate the immune response and can treat immune diseases and conditions of immune overactivation.

5. Skin Health:

The anti-inflammatory properties of PEA may also be used in the treatment of skin conditions characterized by inflammation and itching. Examples include eczema, psoriasis, and atopic dermatitis.

7. Urinary Health:

PEA’s anti-inflammatory and pain-relieving effects are beneficial in managing conditions like interstitial cystitis and chronic prostatitis.

8. Allergic Reactions:

The modulatory effects of PEA on mast cells and immune responses can be used to control allergic and hypersensitivity reactions.

9. Endometriosis and Pelvic Pain:

PEA’s anti-inflammatory effects and potential effects on nerve-related pain may be useful in the treatment of endometriosis and chronic pelvic pain.

Synthesis of Palmitoylethanolamide

The preparation of palmitoylethanolamide (PEA) can be achieved through various synthetic routes.

Here’s a simplified overview of the preparation process:

Synthesis of Palmitoylethanolamide:


Palmitic acid
Solvent (e.g., toluene, ethanol)
Catalyst (e.g., sulfuric acid, hydrochloric acid)


  1. Esterification: Palmitic acid (a fatty acid) is reacted with ethanolamin in the presence of a solvent and an acid catalyst. The acid catalyst helps facilitate the amidation reaction by promoting the formation of an ester intermediate.
  2. Amidation: The ester intermediate formed in the previous step undergoes amidation. This involves the replacement of the ester oxygen with the amino group from ethanolamin, resulting in the formation of palmitoylethanolamide.
  3. Neutralization and Purification: After the reaction is complete, the mixture is neutralized to remove any excess acid catalyst. The resulting crude product is then purified through methods such as filtration, crystallization, and solvent extraction to obtain pure palmitoylethanolamide.
  4. Drying and Characterization: The purified palmitoylethanolamide is dried and characterized using techniques like melting point determination, spectroscopy (e.g., infrared spectroscopy), and chromatography (e.g., high-performance liquid chromatography).


It’s important to mention that the synthesis of PEA should be conducted by trained professionals in a controlled laboratory setting, as it involves the use of potentially hazardous chemicals and reaction conditions. So if you need the best palmitoylethanolamide of high quality and purity. Looking for Manufacturers or Suppliers of Palmitoylethanolamide for sale. Then contact Nature Micron. We will provide you with free samples for testing and professional technical support.

Palmitoylethanolamide Safety and Risk

While PEA is safe for most people, it’s essential to understand its potential chemical safety considerations and risks.

Chemical Safety:

Biocompatibility: PEA is an endogenous compound. This suggests that PEA has some degree of biocompatibility as the body becomes accustomed to its presence.

Non-toxic: The safety of PEA has been extensively studied. Clinical trials and studies have shown no significant side effects when used within the recommended dosage.

Potential Risks:

DRUG INTERACTIONS: Consult a healthcare professional if you take other medications, especially those affecting the endocannabinoid system or related pathways.

Hypersensitivity reactions: Hypersensitivity reactions to PEA are extremely rare, but cannot be completely ruled out.

Dosage: Although PEA is safe, follow the recommended dosage given by your healthcare professional or on the product label.

Palmitoylethanolamide TDS.pdf

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