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Fursultiamine (CAS: 804-30-8)

Fusultiamine is a drug and vitamin, a derivative of vitamin B1. It is suitable for the treatment of Beriberi or Wernicke encephalopathy caused by vitamin B1 deficiency, and it can also be used as an auxiliary treatment for peripheral neuritis and indigestion caused by vitamin B1 deficiency. It can quickly transform into active thiamine in the body, that is, cocarboxylase, and is not decomposed by thiaminase in the body. It has a strong affinity to tissues and a long retention time.

Cas Number: 804-30-8

EINECS Number: 212-357-1

Molecular Formula: C17H26N4O3S2

Structure Formula: 

Appearance:  White or light yellow crystalline powder

Other Name: Thiamine tetrahydrofurfuryl disulfide; TTFD; Fursultiamin; Diteftin

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Application of Fursultiamine

Thiamine tetrahydrofurfuryl disulfide is quickly converted into active thiamine in the body and is not decomposed by thiamine enzymes. It has a strong affinity to tissues, high concentrations in organs and blood, and a long maintenance time. It has the advantages of high efficiency, long-term effect, and low toxicity.

Fursultiamin is suitable for treating vitamin B1 deficiency beriberi or Wernicke encephalopathy. It can also be used as an adjuvant treatment for peripheral neuritis and indigestion caused by vitamin B1 deficiency.

Parameters of Thiamine tetrahydrofurfuryl disulfide (TTFD)

Items Specification
Name Fursultiamine
Other Name Thiamine tetrahydrofurfuryl disulfide; TTFD; Fursultiamin; Diteftin
Brand Natural Micron Pharm Tech
Cas Number 804-30-8
EINECS Number 212-357-1
Appearance White or light yellow crystalline powder
Molecular Formula C17H26N4O3S2
Structure Formula
Molecular Weight 398.54
Melting Point 130-136°C (decompos.)
Solubility Soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
Purity (HPLC) 98.0-102.0%
Boiling point 652.3±55.0°C(Predicted)
Place of Origin China
Shelf Life 2 Years
Package 25kg/drum, small sample available
Storage Store in Dry and Ventilated place with the Room Temperature, Preserved in Original Tight-Closed containers, Keep Away from Light and Heating.

What is Fursultiamine?

Fusulthiamine (CAS No. 804-30-8), also known as thiamine tetrahydrofurfuryl disulfide, is a synthetic derivative of thiamine (vitamin B1), a Water-soluble B vitamins essential for physiological function.

Therefore, it can be said that fursultiamine is a more stable fat-soluble thiamine with a higher application value. It aims to overcome some of the limitations of conventional thiamine, such as its susceptibility to degradation under heat, oxygen, and alkaline conditions.

Today, fursultiamine is used primarily as a dietary supplement and as a therapeutic agent in the treatment of conditions associated with thiamine deficiency, such as beriberi and Wernicke-Korsakoff syndrome.

Fursultiamine Biological/Chemical Reaction

Following are some important reactions and processes of fursultiamine:

  1. Absorption and Biotransformation: After oral intake, fursultiamine is enzymatically hydrolyzed by thiolase in the digestive tract, releasing two molecules of thiamine tetrahydrofurfuryl disulfide.
  2. Coenzyme Action: Thiamine and its derivatives, including the active form derived from fursultiamine, act as coenzymes in many enzymatic reactions. For example, it acts as a coenzyme in the decarboxylation reaction in carbohydrate metabolism.
  3. Branched-chain amino acid metabolism: TPP is the coenzyme that catalyzes the first step in the catabolism of branched-chain amino acids.
  4. Nervous system function: Thiamine participates in the synthesis of neurotransmitters such as acetylcholine.
  5. Role in oxidative decarboxylation: TPP assists oxidative decarboxylation reactions by stabilizing carbanion intermediates and facilitating the transfer of intermolecular hydroxyethyl groups.

Uses of Fursultiamine

Here are some of its main uses:

  1. Dietary Supplement: Fusultiamine is often used as a dietary supplement to provide the body with an effective source of thiamine. It can be used to treat diseases caused by thiamine deficiency, such as beriberi and Wernicke-Korsakoff syndrome.
  2. Improved Absorption: Fursultiamine enhances the absorption of thiamine compared to traditional thiamine supplements.
  3. Enhanced cellular uptake: The enhanced cellular uptake of fursultiamine helps address situations where thiamine transport into cells may be impaired.
  4. Energy Production: Thiamine is essential for the conversion of carbohydrates into energy.
  5. Nervous system health: fursultiamine provides adequate thiamine which can contribute to normal nerve function and neurotransmitter synthesis.
  6. Athletic performance: Some athletes use thiamine supplements, including fursultiamine, to support energy levels during vigorous physical activity.

Fursultiamine Preparation Method

It is usually prepared by chemical reactions, the exact synthetic route may involve several steps, the following is an overview of the preparation method:

  1. Raw material: The raw material for the synthesis of fursultiamine is thiamine hydrochloride or thiamine mononitrate.
  2. Protection of Thiamine: Thiamine is modified to temporarily protect specific functional groups that need to remain unchanged in subsequent reactions.
  3. Furoylation: The protected thiamine molecule reacts with furfurylamine, resulting in the replacement of hydroxyl groups with furfuryl groups.
  4. Disulfide Bond Formation: The final step is the formation of a disulfide bond between two modified thiamine molecules.
  5. Deprotection: If a protecting group is used in the initial step, it is removed at this stage to expose the functional group to the desired position.
  6. Purification and Isolation: The resulting fursultiamine compound is then purified and isolated from the reaction mixture. Various purification techniques, such as crystallization or chromatography, may be employed to obtain pure products.
  7. Characterization: The synthesized fursultiamine compound was thoroughly characterized using techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy, and infrared spectroscopy to confirm its structure and purity.

Due to the complexity of organic synthesis and the need for specialized equipment and expertise, the preparation of fursultiamine is usually performed by skilled chemists in research or pharmaceutical laboratories. If you need Thiamine Tetrahydrofurfuryl Disulfide for your project. Contact us today for high-purity products. Natural Micron provides free samples and professional technical support.

Fursultiamine Safety and Risks

Fursultiamine is generally safe when taken as a dietary supplement or pharmaceutical preparation. However, it also has certain potential risks, the following are the specific contents:

Security considerations:

  1. Toxicity: Fursultiamine is less toxic in vivo than its precursor, thiamine hydrochloride, even at high doses.
  2. Side effects: Fursultiamine is well tolerated by most people. However, it may also cause mild gastrointestinal distress, especially in higher doses.
  3. Hypersensitivity reactions: Hypersensitivity reactions to fursultiamine are rare.

Risks and Precautions:

  1. Dosage: Fursultiamine supplements should be taken at the recommended dose.
  2. Pregnancy and breastfeeding: Pregnant and breastfeeding women should consult their healthcare provider before taking fusultiamine supplements.

Fursultiamine Research and Future Development

Research on fursultiamine has largely focused on its potential therapeutic applications, mechanism of action, and advantages over traditional thiamine supplements.

Below are some areas of research and potential future developments related to fursultiamine :

1. Therapeutic application:

Neurological disorders: The enhanced bioavailability of fursultiamine makes it a potential candidate for the treatment of neurological disorders associated with thiamine deficiency, such as Wernicke-Korsakov syndrome and various neuropathies.

Alzheimer’s disease: Some research suggests that thiamine deficiency may be linked to cognitive decline and Alzheimer’s disease. The potential of fursultiamine in addressing thiamine-related cognitive problems may require further exploration.

2. Mechanism of action:

Enhanced Bioavailability: Research can delve deeper into how fursultiamine improves thiamine absorption and utilization compared to traditional thiamine supplements.

Cellular Uptake: Understanding how cells take up fursultiamine and how it interacts with cellular processes can provide insight into its therapeutic effects.

3. Comparative research:

Comparison to Thiamine: Ongoing research comparing the effects of fursultiamine with traditional thiamine supplements can highlight the advantages and potential disadvantages of each form.

4. Neuroprotective effect:

Oxidative Stress: Investigation of furathiamine’s potential to reduce oxidative stress in neural tissues may open new avenues for its use in neuroprotection.

6. Combination therapy:

Synergistic effects: Exploring whether fursultiamine can enhance the therapeutic effects of other neuroprotective compounds may lead to the development of combination therapies.

7. Other health applications:

Metabolic health: investigating whether fursultiamine plays a role in metabolic disorders such as diabetes and obesity due to its involvement in energy metabolism.

8. Formulation and delivery:

Innovative formulations: The development of novel formulations, such as extended-release formulations, can optimize the bioavailability and therapeutic effect of fursultiamine.

Fursultiamine COA.pdf

Fursultiamine TDS.pdf

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