Dihydrohonokiol-B (CAS: 219565-74-9)

What is Dihydrohonokiol-B

Dihydrohonokiol-B is a reduced derivative of magnolol. It is mainly extracted from honokiol through a reduction process. Dihydrohonokiol-B has multiple effects, including antioxidant, anti-inflammatory, antitumor, antibacterial, anxiolytic, antidepressant, and neuroprotective.

DHH-B has a specific chemical structure derived from the reduction of honokiol. It consists of multiple aromatic rings and functional groups, and it also has very unique properties in terms of solubility and stability. Therefore, it has great potential and research value in regulating neurotransmitter receptors, reducing oxidative stress, preventing neuronal damage, and inhibiting cancer cell growth

Dihydrohonokiol Biological/Chemical Reaction

Here are some biological and chemical reactions that DHH-B may undergo:

1. Oxidation: Dihydrohonokiol-B can undergo oxidation reactions, converting it back to its parent compound honokiol.
2. Metabolism: In biological systems, Dihydrohonokiol-B can undergo enzymatic metabolism, where it is modified by various enzymes in the body.
3. Binding to Receptors or Proteins: Dihydrohonokiol-B can interact with specific receptors or proteins in the body, modulating their activity or function.
4. Chemical Modifications: Dihydrohonokiol-B can undergo chemical modifications, such as acylation, methylation, or other functional group modifications.
5. Reactive Oxygen Species (ROS) Scavenging: Dihydrohonokiol-B can react with reactive oxygen species (ROS) and free radicals, neutralizing their harmful effects and protecting cells from oxidative damage.

Application of DHH-B

Dihydrohonokiol-B has a very wide range of applications, the following are some practical applications of Dihydrohonokiol-B

1. Neuroprotection: Dihydrohonokiol-B can protect neuronal cells from oxidative stress, reduce neuroinflammation, and promote neuronal survival.
2. Anxiety and antidepressant effects: Dihydrohonokiol-B has anxiolytic and antidepressant properties. It improved anxiety-like behavior and depressive symptoms in animals in animal experiments.
3. Anti-inflammatory activity: Dihydrohonokiol-B counteracts inflammation by inhibiting the production of pro-inflammatory cytokines and the activation of inflammatory pathways.
4. Anticancer potential: Dihydrohonokiol-B can inhibit the growth of various cancer cells and induce apoptosis of cancer cells.
5. Antimicrobial properties: Dihydrohonokiol-B is resistant to a variety of bacteria and fungi.
6. Skin health and cosmetics: Dihydrohonokiol-B may promote skin health. It protects the skin from oxidative stress, reduces inflammation, and maintains skin barrier function.

Synthetic method of Dihydrohonokiol-B

Here is a general outline of a synthetic approach for Dihydrohonokiol:

1. Start with Honokiol: Honokiol is commercially available or can be extracted from natural sources such as the bark of Magnolia species. It serves as the starting material for the synthesis of Dihydrohonokiol-B.
2. Reduction: Honokiol is subjected to a reduction reaction to convert it into Dihydrohonokiol-B. This reduction can be achieved through various methods, such as catalytic hydrogenation or using reducing agents like sodium borohydride (NaBH4).
3. Purification: After the reduction step, the reaction mixture is purified to isolate and obtain the desired Dihydrohonokiol-B compound. Purification techniques include solvent extraction, column chromatography, or recrystallization.
4. Characterization: The obtained Dihydrohonokiol-B compound is then characterized using various analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and infrared spectroscopy to confirm its identity and assess its purity.

Safety and risk

DHH-B should be handled and used with appropriate safety precautions. Here are some considerations about the safety and potential risks of dihydrohonokiol-B:

1. Personal Protective Equipment (PPE): When handling dihydrohonokiol-B, appropriate personal protective equipment such as gloves, goggles, and a lab coat is recommended to minimize direct skin contact and eye exposure.
2. Inhalation and Skin Contact: Dihydrohonokiol-B should be handled in a well-ventilated area. In case of skin contact, wash the affected area immediately with soap and water. If irritation persists, get medical attention.
3. Storage and Stability: Dihydrohonokiol-B should be stored in a cool, dry, well-ventilated area away from direct sunlight.
4. Fire and Explosion Hazard: Dihydrohonokiol-B is not a highly flammable chemical. However, users are required to follow standard laboratory safety practices and guidelines for handling flammable chemicals to prevent fire hazards.
5. Environmental Impact: It is important to handle and dispose of Dihydrohonokiol-B according to local regulations and environmental guidelines.

Research and development

Dihydrohonokiol-B has great research value. In addition to the existing applications, it can also focus on the research and development of the following aspects.

1. Pharmacological studies: Further studies are needed to explore the therapeutic applications of dihydrohonokiol-B in various fields.
2. Formulation Development: Development of suitable Dihydrohonokiol-B formulation and delivery system.
3. Structure-Activity Relationship (SAR) Study: Exploring the structure-activity relationship of dihydrohonokiol-B helps identify key structural features and modifications that contribute to its biological activity.
4. Mechanistic studies: Studying the molecular mechanism of the biological effects of dihydrohonokiol-B can provide valuable insights into its mode of action and potential molecular targets.