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Cytidine 5′-Diphosphocholine (CAS: 987-78-0)

Cytidine 5′-diphosphocholine is a nucleoside derivative. It is used to treat stroke, head trauma or injury, Alzheimer’s disease, Parkinson’s disease, and glaucoma. A stroke occurs due to insufficient blood supply to the brain. Citicoline can improve the state of consciousness and EEG of consciousness disorder after head trauma or brain surgery, promote the recovery of upper limb motor function in stroke hemiplegia patients, and has a certain effect on promoting the recovery of brain function and waking up.

Cas Number: 987-78-0

EINECS Number: 213-580-7

Molecular Formula: C14H26N4O11P2

Structure Formula:

Appearance:  White crystalline powder

Other Name: Cytidine diphosphate choline; Citicoline; Cytidine 5′-diphosphate Choline

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Application of Cytidine diphosphate choline

Cytidine 5′-Diphosphocholine is widely available internationally as a supplement, which was originally developed in Japan for the treatment of acute cerebrovascular disorders.

Citicoline can improve learning, memory, judging, and thinking processes. And improve recovery in patients with disturbance in consciousness in patients with head injury or any other problems associated with the brain and who underwent surgery.

Cytidine diphosphate choline has been investigated for the treatment of depression, schizophrenia, stroke, Parkinson disease, brain injury, and cognitive deficits (ie, mild to moderate dementia and Alzheimer disease, cerebrovascular disorders), as well as for its ophthalmologic effects.

Supplementation with Cytidine 5′-diphosphate Choline increases choline stores available for other biosynthetic pathways.

Citicoline appears to decrease glutamate levels in the brain and increase adenosine triphosphate, which in turn offers protection against ischemic neurotoxicity. Increased glucose metabolism in the brain and cerebral blood flow has also been demonstrated, as well as increased availability of the neurotransmitters acetylcholine, norepinephrine, and dopamine.

Cytidine 5′-Diphosphocholine can promote the rapid repair of damaged cell surfaces and mitochondrial membranes, maintain cell compactness and biological functions, and reduce the release of free fatty acids, thereby reducing the generation of toxic oxygenated metabolites and free radicals.

Citicoline increases vasopressin and plasma epinephrine levels and stimulates the release of growth hormone, thyrotropin, and luteinizing hormone.

Parameters of Citicoline

Items Specification
Name Cytidine 5′-Diphosphocholine
Other Name Cytidine diphosphate choline; Citicoline; Cytidine 5′-diphosphate Choline
Brand Natural Micron Pharm Tech
Cas Number 987-78-0
EINECS Number 213-580-7
Appearance White crystalline powder
Molecular Formula C14H26N4O11P2
Structure Formula
Molecular Weight 488.33
Assay 98.0%-102.0%
PH 2.5-3.5
5′-CMP ≤1.0%
Loss on Drying ≤5.0%
Heavy Metal ≤10ppm
Melting Point >185°C (dec.)
Solubility Water (Sparingly)
Place of Origin China
Shelf Life 2 Years
Package Aluminum Foil Bag/Drum
Storage Store in dry and ventilated place with the room temperature. Preserved in original tight-closed containers. Keep away from light and heating.

Cytidine 5′-Diphosphocholine COA.pdf

Cytidine 5′-Diphosphocholine TDS.pdf

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