Natural Micron Pharm Tech


Amarogentin (CAS: 21018-84-8)

Amarogentin is a bitter compound and one of the major active ingredients found in the plant species Gentiana lutea, commonly known as Gentian.

Amarogentin is a secoiridoid glycoside, which means it is a compound composed of a secoiridoid aglycone (the bitter part) and a sugar molecule (glycoside) attached to it. It has antioxidant, antitumor and antidiabetic effects.

Cas Number: 21018-84-8

EINECS Number: N/A

Molecular Formula: C29H30O13

Structure Formula:

Appearance: White Powder

Other Name: Amarogentina

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Application of Amarogentin

Traditional uses

The bitter taste of Amarogentin has led to its traditional use in herbal medicine and the beverage industry. In traditional medicine, Amarogentin-containing preparations are believed to have digestive and appetite-stimulating properties. It is also used in the formulation of various herbal remedies for supporting digestive health.

In the beverage industry, Amarogentin is responsible for the characteristic bitter taste of beverages made from Gentian, such as Gentian liqueur or bitters. These bitter beverages are often used as aperitifs, believed to stimulate the appetite before a meal.

Modern scientific research

Studies have shown that Amarogentin and other bitter compounds in Gentian may have various biological activities, including antioxidant, anti-inflammatory, and hepatoprotective properties.

Amarogentin has the effects of protecting the liver and gallbladder, inhibiting bacteria, and diuresis.

Amarogentin, an agonist of the bitter taste receptor TAS2R1, inhibits substanceP-induced production of newly synthesized TNF-α in LAD-2 cells.

Amarogentin induces apoptosis of human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signaling pathway.

Amarogentin (AG) can interact with the α2 subunit of AMP-activated protein kinase (AMPK) and activate trimer kinase.

Parameters of Amarogentina

Items Specification
Name Amarogentin
Other Name Amarogentina
Brand Natural Micron Pharm Tech
Cas Number 21018-84-8
Appearance White powder
Molecular Formula C29H30O13
Structure Formula
Molecular Weight 586.54
Purity(HPLC) ≥98.94%
Melting point 229-230° (monohydrate)
Alpha D20 -116.6° (methanol)
Solubility DMF: 1 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.1 mg/ml
Place of Origin China
Shelf Life Under the transportation and storage conditions specified in this standard, the shelf life is two years from the date of production if the packaging is complete and unopened.
Package The product is packed and sealed in drums or bags that do not affect the quality of the product.
Storage 2-8℃,protected from light,keep package airproofed when not in use.

What is Amarogentin?

Amarogentin (CAS No: 21018-84-8. or Amarogentina. I don’t know why there is an extra “A”) is a compound that belongs to the class of natural products iridoid glycosides. It is an iridoid glycoside consisting of iridoid aglycone and multiple sugar moieties.

Amarogentin is mainly found in the roots of the yellow gentian plant. Therefore, it is incorporated into herbal formulas and dietary supplements. In traditional medicine systems, Amarogentin promotes liver, digestion, and general health. It is also used to treat digestive disorders, stimulate appetite, and support liver function.

Uses of Amarogentin

Due to the properties of Amarogentin, it has been explored for various potential uses. Here are some potential uses of amarogentin:

1. Traditional medicine:

Amarogentin has a long history of use in traditional herbal medicine, especially in Ayurveda and traditional European herbal medicine. It is mainly used to improve digestion, protect the liver and stimulate appetite.

2. Digestive health:

Amarogentin’s bitter taste stimulates digestion by stimulating the release of digestive enzymes and increasing bile production. This can aid digestion and relieve problems like indigestion and gas.

3. Liver support:

Amarogentin helps protect liver cells from oxidative stress and inflammation and helps detoxify the liver.

4. Antioxidant activity:

Amarogentin has antioxidant properties, which neutralize harmful reactive oxygen species (ROS) in the body.

5. Weight management:

Bitter compounds in bitter compounds affect appetite regulation and metabolism. Can be used for weight control.

Amarogentin Preparation Method

Preparing amarogentin involves extracting it from the plant sources where it naturally occurs.

One of the primary plant sources of amarogentin is the herb Gentiana lutea.

Here’s a general outline of the preparation method:

  1. Plant Collection: Harvest the roots or other plant parts of Gentiana lutea that contain amarogentin.
  2. Drying: Dry the collected plant material to reduce moisture content, which helps in preservation and subsequent extraction.
  3. Size Reduction: Grind the dried plant material into a fine powder to increase the surface area for extraction.
  4. Extraction: Use a suitable solvent (often ethanol or methanol) to extract the bioactive compounds from the plant material. The plant material is mixed with the solvent and allowed to macerate over a certain period. This process extracts amarogentin and other compounds present in the plant.
  5. Filtration: After maceration, filter the solvent-extract mixture to separate the liquid extract from the solid plant residue.
  6. Concentration: The liquid extract is then concentrated using methods like rotary evaporation or freeze-drying to remove the solvent and obtain a more concentrated extract.
  7. Purification: Further purification steps such as column chromatography or liquid-liquid extraction may be employed to isolate amarogentin from other compounds in the extract.
  8. Crystallization: Amarogentin can be isolated by crystallization from the purified extract using appropriate solvents and controlled cooling or evaporation methods.
  9. Characterization: Analytical techniques like nuclear magnetic resonance (NMR), mass spectrometry, and high-performance liquid chromatography (HPLC) are used to confirm the identity and purity of the isolated amarogentin.

Note: The exact preparation method can vary based on factors like the plant source, available equipment, and specific extraction techniques employed by researchers or manufacturers.

It’s worth mentioning that the extraction of amarogentin can be challenging due to its complex chemical structure and the presence of other compounds in the plant source.

Therefore, if you need amarogentin and you want a product of high quality and purity. Please get in touch with Natural Micron. We provide professional technical support as well as free samples for your testing.

Amarogentina Safety and Risks

Amarogentin is a natural compound found in plants. Therefore, it is safer than chemically synthesized compounds, but it also has certain risks. The following is a specific introduction.

Chemical Safety:

  • Natural Source: Amarogentina is found in Gentiana plants. So it is relatively safe.
  • Purity: Different manufacturers sell amarogentina in varying degrees of purity and quality. So it is very important to find a reputable manufacturer that produces specifications.

Potential Risks:

  • Allergic reaction: Seek medical attention if you experience symptoms such as itching, rash, swelling, or trouble breathing after consuming amygdalin products.
  • Indigestion: In some cases, consuming products rich in amygdalin may cause digestive discomfort, including nausea, vomiting, or an upset stomach.

Amarogentin Research and Future Development

Amarogentin is of great interest for its potential health benefits and therapeutic applications. Amarogentin in particular belongs to a class of naturally occurring compounds.

The following are some specific research directions:

  • Pharmacological properties: amarogentin is worth studying in terms of anti-inflammatory, anti-oxidation, hepatoprotective, and anti-diabetic effects. The goal is to understand how it works.
  • Gastrointestinal health: In traditional medicine, plants containing amarogentin have been used to promote digestive and liver health. Explore the possibility of treating other gastrointestinal and digestive diseases by studying how it works.
  • Cancer research: Amarogentin may have anticancer properties. This is well worth looking into.
  • Metabolic Disorders: Amarogentin may have the potential to treat metabolic disorders such as diabetes and obesity. Its ability to regulate blood sugar levels and improve insulin sensitivity is well worth studying.

Amarogentin COA.pdf

Amarogentin TDS.pdf

Amarogentin MSDS.pdf

Amarogentin HPLC.pdf

Amarogentin C.pdf

Amarogentin H.pdf

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