(S)-MonoPhos

Product Name: (S)-MonoPhos

Other Name: (R)-MONOPHOS

CAS No.: 185449-80-3

Chemical Structure:

(S)-MonoPhos Application:

(S)-MonoPhos is a chiral phosphine ligand widely utilized in asymmetric catalysis and enantioselective synthesis. Structurally, it features a monodentate phosphoramidite framework that provides strong coordination ability and high enantioselectivity when complexed with transition metals such as rhodium, palladium, or ruthenium.
Due to its chiral backbone and versatile coordination environment, (S)-MonoPhos plays a crucial role in the development of modern catalytic systems for the production of optically pure compounds. It has become an essential ligand in asymmetric hydrogenation, hydroformylation, and allylic substitution reactions. Its unique structure allows fine-tuning of both steric and electronic properties, offering high conversion efficiency and selectivity even under mild reaction conditions. This balance of performance and stability has made (S)-MonoPhos a preferred ligand for researchers and industrial manufacturers engaged in pharmaceutical and fine chemical synthesis. Applications:

1. Asymmetric Hydrogenation Catalyst
   (S)-MonoPhos is frequently employed as a ligand in rhodium- or ruthenium-catalyzed asymmetric hydrogenation. It enables precise control over stereochemistry, facilitating the production of enantiomerically pure alcohols, amines, and carboxylic acids widely used in pharmaceutical intermediate synthesis.

2. Hydroformylation and Cross-Coupling Reactions
   The compound is used in metal-catalyzed hydroformylation and C–C bond-forming reactions. Its strong coordination with transition metals ensures excellent regioselectivity and stability, making it suitable for large-scale production of fine chemicals and intermediates.

3. Pharmaceutical and Fine Chemical Synthesis
   (S)-MonoPhos supports the synthesis of chiral molecules and intermediates that serve as building blocks for APIs and specialty materials. Its reliability and reproducibility make it indispensable in developing sustainable catalytic processes in both R&D and industrial environments.

(S)-MonoPhos Packaging and Shipping:

Packaging: 10g/bag, 100g/ bag, 1kg/bag or as customer’s required.

Shipping : DHL/ FedEx/ Air shipping

(S)-MonoPhos Storage:

Please store in a well ventilated, dry place at 2-8 ℃ and avoid direct sunlight.