Product Name: N-(p-Toluenesulfonyl)-2-pyrroline
Other Name: 1-Tosyl-2,3-dihydro-1H-pyrrole
CAS No.: 130719-30-1
Chemical Structure:
N-(p-Toluenesulfonyl)-2-pyrroline Application:
N-(p-Toluenesulfonyl)-2-pyrroline is a highly valuable organic intermediate widely utilized in pharmaceutical synthesis, asymmetric catalysis, and fine chemical production. It consists of a p-toluenesulfonyl protecting group attached to a 2-pyrroline ring, giving it remarkable chemical stability and reactivity balance. The compound typically appears as a white to off-white crystalline solid with excellent solubility in most organic solvents such as dichloromethane, chloroform, and toluene.
As a protected pyrroline derivative, this compound plays a crucial role in multi-step organic synthesis. The p-toluenesulfonyl (Ts) group serves as an electron-withdrawing protective moiety that stabilizes nitrogen-containing intermediates, making it suitable for the preparation of heterocycles, chiral amines, and bioactive molecules. It is particularly valuable in constructing nitrogen-based frameworks common in pharmaceuticals, including alkaloid analogs, enzyme inhibitors, and CNS-targeting molecules.
In industrial and research applications, N-(p-Toluenesulfonyl)-2-pyrroline acts as a substrate or ligand precursor in transition-metal catalyzed reactions, such as palladium-catalyzed cross-coupling and oxidation processes. Its controlled reactivity enables precise structural modifications, supporting the development of advanced intermediates in medicinal chemistry and material sciences.
Due to its high purity and consistent performance, it is often employed in synthetic chemistry laboratories and large-scale production for pharmaceuticals, agrochemicals, and functionalized fine chemicals. With its strong stability and predictable chemical behavior, this compound supports innovation in high-value chemical synthesis. Applications:
Pharmaceutical Intermediate
Used in the synthesis of nitrogen-containing drug molecules and chiral intermediates, supporting the preparation of active pharmaceutical ingredients (APIs).Catalyst and Ligand Precursor
Serves as a precursor in metal-catalyzed organic reactions, including amination, oxidation, and coupling, enhancing synthetic efficiency in research and industry.Fine Chemical and Specialty Material Synthesis
Applied in designing specialty fine chemicals and advanced organic materials, contributing to molecular diversification and performance optimization.
N-(p-Toluenesulfonyl)-2-pyrroline Packaging and Shipping:
Packaging: 1kg/ bag, 25kg/ drum or as customer’s required.
Shipping : DHL/ FedEx/ Air shipping/ Ocean shipping
N-(p-Toluenesulfonyl)-2-pyrroline Storage:
Store in Dry and Ventilated place with the Room Temperature, Preserved in Original Tight-Closed containers, Keep Away from Light and Heating.
