1-Methylnicotinamide Chloride (1-MNA) is a highly effective endogenous metabolite of nicotinamide, widely utilized in dietary supplements and functional formulations. With a formula C₇H₉ClN₂O (CAS 1005-24-9), our high-purity 1-Methylnicotinamide Chloride is tailored for B2B applications in nutraceuticals, pharmaceuticals, and cosmetics.
What is 1-Methylnicotinamide Chloride?
1-Methylnicotinamide Chloride (1-MNA) is the chloride salt form of 1-MNA, a metabolite produced via nicotinamide N-methyltransferase (NNMT). The chloride variant ensures stability and regulatory approval for use in food supplements in the EU and beyond.
Why Choose 1-Methylnicotinamide Chloride?
1. Authorised for Food Supplements
In the EU, 1-MNA chloride stands out as a legally recognised novel food ingredient. Its authorisation offers supplement brands an advantage: an ingredient with proven regulatory approval and established intake limits. This helps product developers bring compliant formulations to market more quickly.
2. Listed in Cosmetic Ingredient Databases
1-MNA is included in the EU CosIng database under the INCI name Methyl Niacinamide Chloride. Recognised as a skin-conditioning agent, it can be formulated into creams, serums, and topical emulsions. Cosmetic brands increasingly look for novel actives that complement established ingredients like niacinamide, and 1-MNA provides a natural extension of this trend.
3. Valued in Research & Development
1-MNA chloride is widely used in scientific and biomedical research. Studies have explored its involvement in nitric oxide pathways, prostacyclin (PGI₂) production, and endothelial biology. It has also been investigated in dermatology models for skin health and appearance. For laboratories, it offers a well-characterised material for exploring new mechanisms.
What are the benefits of 1-Methylnicotinamide Chloride (1-MNA)?
High Purity and Consistency
Produced under strict quality standards, 1-MNA ensures reliable performance for use in research, formulation, and ingredient development.Versatile Applications
Its unique molecular properties make it suitable for use in nutraceutical formulations, cosmetic innovation, and biochemical research, supporting a wide range of B2B needs.Market Growth Potential
With increasing interest in next-generation NAD⁺ metabolism-related ingredients, 1-MNA has attracted attention from industries seeking differentiation and competitive product development.
Why Source from Natural Micron Pharm?
High Purity: ≥98% HPLC-tested material
Full Documentation: COA, TDS, SDS, and COO provided with each batch
Flexible Supply: Global shipping, adaptable MOQs, and consistent lead times
Expert Support: Technical assistance for supplement, cosmetic, and R&D formulations
📩 Next Step: Contact us today to request a sample, pricing information, or technical consultation and accelerate your next product launch.
Regulatory & Safety Background
In 2017, the European Food Safety Authority (EFSA) concluded that 1-MNA chloride is safe for use in food supplements for adults under specific conditions.
In 2018, the European Commission authorised it as a novel food ingredient. The approval allows use only in food supplements for healthy adults, excluding pregnant and lactating women, with a maximum intake of 58 mg per day.
In the cosmetics field, 1-MNA is registered in the EU CosIng database under the INCI name Methyl Niacinamide Chloride, recognised as a skin-conditioning agent.
Compliance Note: Manufacturers must always follow local laws when using 1-MNA in supplements or cosmetic formulations.
FAQs
Q1: How is 1-Methylnicotinamide Chloride different from Niacinamide?
It is a methylated metabolite of niacinamide with distinct biochemical properties and applications.
Q2: Is 1-MNA approved for supplements in the EU?
Yes, it is authorised as a novel food ingredient for use in supplements for adults, with a 58 mg/day limit.
Q3: Can I use 1-MNA in cosmetic formulations?
Yes, it is listed in the EU CosIng database under the INCI name Methyl Niacinamide Chloride and recognised as a skin-conditioning ingredient.
Q4: What documents are provided with each order?
We supply COA, TDS, SDS, and additional regulatory support documents as required.
