Natural Micron Pharm Tech


Hinokitiol: Definition, Uses, Side Effects

Hinokitiol is a naturally occurring compound found in the cypress species and has a wide range of uses. So, do you know what specific uses hinokitiol has? What are the side effects? In this article, Natural Micron will detail the definition, uses, and side effects of hinokitiol.

Now, let’s get started!

What is hinokitiol?

Hinokitiol is a monoterpene natural compound with a tropolone skeleton extracted from the trunk of a Taiwanese cypress. It belongs to the tropolone family of compounds. It was first discovered by Japanese scientist Anderson in 1948. Because hinokitiol has good antibacterial properties, moisturizing properties and pest-repellent effects, it is mainly used as an antibacterial and insect-repellent agent to prevent pests from invading the human body, inhibit human pathogenic bacteria, etc.

The structure of the hinokitiol compound consists of a central five-membered ring containing an oxygen atom and various hydrogen (H) atoms attached to carbon atoms. Its structural diagram is as follows:

|   |   |   |   |   |   |

Its chemical and physical properties are as follows:

Melting point: 50-52℃. Boiling point: 140℃. Density: 1.0041. Refractive index: 1.5190. Soluble: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Form: Solid. Acidity coefficient: 7.06±0.30 (Predicted). Color: White. Fragrance: Woody.

For more information about the compound hinokitiol, you can check out this page. Now, let’s take a look at some of the powerful applications of hinokitiol.

What is the use of hinokitiol?

The minimum inhibitory concentration of hinokitiol for general bacteria is 10-100ppm. It has a fragrant smell and good effect. It can kill bacteria, microorganisms, etc. in the air, so it is used in many nursing and pharmaceutical products.

Antibacterial, anti-inflammatory, and antiseptic properties: As a compound with strong antibacterial, anti-inflammatory, and antiseptic properties, hinokitiol plays an important role in personal care products (skin care products, oral care products), cosmetics, medicine, etc.

Hinokiniol is found in many skin care treatments. For example, in the application of whitening agents, tyrosinase is a key enzyme in the formation of melanin. It can catalyze the conversion of leucine and dopa into eumelanin, brown pigment, etc. through multiple pathways in the human body, thereby causing the formation of freckles, chloasma, and pregnancy spots. Hinokitiol has a strong inhibitory effect on tyrosinase bisphenolase, thereby whitening and protecting the skin.

Hair Growth: Hinokitiol has a powerful effect in promoting hair growth. Its main functions are as follows:

  • Inhibit the growth of harmful microorganisms and prevent dandruff, scalp inflammation and other diseases that hinder hair growth.
  • Protects hair follicles from damage caused by oxidative stress and free radicals.
  • Relax the blood vessels of the scalp and promote blood circulation.
  • Regulates sebum production on the scalp.
  • Supports the production of keratin, the protein that forms the basis of hair structure.

Hinokitiol promotes hair growth by creating a healthier scalp environment for hair, making it stronger and healthier.

Agricultural uses: As a natural pesticide to protect plants from pests and diseases.

Industrial Uses: Hinokitiol is also widely used in industries such as paints, coatings and textiles.

As a common compound in dairy products, you should pay attention to its potential side effects when using it to ensure your own safety and health. So the following side effects are what you should pay special attention to!

What are the hinokitiol side effects?

There is no clear data on the specific side effects of hinokitiol. But its potential side effects are also worthy of everyone’s attention.

Allergic Reactions: Allergic reactions, such as skin irritation, redness, and itching, may occur when using hinokitiol.

Ingestion: Ingestion of hinokitiol may cause gastrointestinal discomfort, and inhalation of fine particles or smoke of hinokitiol may cause respiratory allergies.

Immune Modulation: Research shows that hinokitiol negatively modulates immune responses. This means it may have an impact on the body’s immune system.

Pregnancy and breastfeeding: Try to avoid using hinokitiol during this time. Or consult a doctor.

Dosage: Actual uses and associated side effects may vary based on specific circumstances and dosage. It is recommended to consult a physician or refer to product-specific safety information.

Here are the data on hinokitiol in rat experiments, including the experimental doses of various parts and the toxicity results of hinokitiol. For your reference.

Acute toxicity: Rat oral LDLo: 500mg/kg, behavior – lethargy (common depressive activity), food intake (animals), gastrointestinal changes;

Mouse intraperitoneal LD50: 85mg/kg, no details except lethal dose;

Mouse subcutaneous LD50: 541mg/kg, behavior – convulsions or epilepsy, analgesia, total nutrition and metabolism and decrease in body temperature;

Mouse intravenous LD50: 128mg/kg, behavior – convulsions or epilepsy, analgesia, total nutrition and metabolism and decrease in body temperature;

Rabbit transdermal LD50: 541 mg/kg, behavior – lethargy (common depressive activity), changes in food intake (animals);

Guinea pig subcutaneous LDLo: 500mg/kg, no details except lethal dose.

In the end

Now, hinokitiol can be said to be one of the best natural compounds, which is widely used and has no obvious side effects. It has positive significance for human health, and agricultural and industrial production. At the same time, hinokitiol is also one of the main products sold by Natural Micron. If you have any needs for hinokitiol, please feel free to contact us for more information.

Leave a Reply

Your email address will not be published. Required fields are marked *

Don’t hesitate to Contact Us!

Reach out to us today and get a complimentary product sample and consultation.